Variability, compensation, and modulation in neurons and circuits

By Eve Marder. Proceedings of the National Academy of Sciences of the United States of America, 2011

372 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

The human connectome: Origins and challenges (2013, background): “structural variability, there is a remarkable level of functional stability or homeostasis, resulting in globally consistent circuit dynamics despite abundant structural variation (Marder, 2011).”
Cell Types, Network Homeostasis, and Pathological Compensation from a Biologically Plausible Ion Channel Expression Model. (2015, positive): “Third, the nervous system is heterogeneous, with many distinct cell types that have specific combinations of ion channels that lend them their unique electrical properties (Marder 2011).”
Neuronal homeostasis: time for a change? (2011, background): “Such a view is compatible with the large degree of variability observed in conductance parameters of cells with a given identity (Marder, 2011), and may explain a larger amount of variation than can be accounted for by random effects.”
Cell Types, Network Homeostasis, and Pathological Compensation from a Biologically Plausible Ion Channel Expression Model (2014, positive): “Third, the nervous system is heterogeneous, with many distinct cell types that have specific combinations of ion channels that lend them their unique electrical properties (Marder 2011).”