Polymorph selection: challenges for the future?

By N. Blagden, R. Davey. 2003

178 citations recorded by the source corpus.

This contribution reviews the area of polymorph selection during solution crystallization using known and predicted structures. In particular, an overview of what has been learned about the relationship between structure and kinetics and of the interplay between thermodynamics and kinetics is presented. This review adds to the debate by discussing the future challenges that we envisage in realizing polymorph selection as a crystal engineering exercise by highlighting the role that a packing landscape approach may contribute in manipulating the selection of a polymorph.

Subfields: Materials Chemistry, Physical and Theoretical Chemistry

View Paper: https://www.semanticscholar.org/paper/937f560a8a3d4e68aaf4e9723c99e047e81c35f6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

1. M. Matas
2. Pauline T. Gavan
3. N. Blagden
4. P. York

Citations in the corpus

• Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates. (2007, background): “In this way it may be able to improve the success rate or selectively engineer a structure [68].”