Glycosylation of Nucleocytoplasmic Proteins: Signal Transduction and O-GlcNAc

By L. Wells, K. Vosseller, Gerald W. Hart. Science, 2001

945 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Organic Chemistry

View Paper: https://www.semanticscholar.org/paper/933ee811c2eeb4f0a8981144902b415e356f7103

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Citations in the corpus

Gibberellin Signaling Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.010476. (2002, background): “O-GlcNAc modification of proteins is a dynamic modification that regulates protein activity (Comer and Hart, 2000; Hanover, 2001; Wells et al., 2001).”
Cycling of O-linked β-N-acetylglucosamine on nucleocytoplasmic proteins (2007, background): “So far, more than 500 proteins have been identified to be O-GlcNAcylated, and these proteins are involved in almost all aspects of cellular metabolis”
Identification and Quantification of Protein Glycosylation (2012, background): “Since the discovery of O-GlcNAc [15], a myriad ofO-GlcNAcylated cytosolic and nuclear proteins have been found in eukaryotes, including transcription and translation factors, metabolic and signaling components, cytoskeletal proteins, oncogenic products, and tumor suppressor proteins [12, 16–21].”
Regulation of epithelial-mesenchymal transition through epigenetic and post-translational modifications (2016, background): “The uridine 5′-diphospho-Nacetylglucosamine (UDP-GlcNAc) is transferred to serine or threonine residues by the O-GlcNAc transferase (OGT) to produce the O-GlcNAc modification, while the removal of the modification is performed by an OGlcNAcase [134, 135].”
Global Analysis of DELLA Direct Targets in Early Gibberellin Signaling in Arabidopsis[W] (2007, background): “The animal OGTs modify target proteins by glycosylation of Ser/ Thr residues, which either interfere or compete with kinases for phosphorylation sites (Wells et al., 2001).”
Cardiac Metabolism and Its Interactions with Contraction, Growth, and Survival of the Cardiomyocte (2013, background): “A positive correlation of cardiac lipid accumulation and cardiac dysfunction has been shown giving rise to the term lipotoxic cardiomyopathy.110–112 Additional studies show that increases of lipid supply in animal models of cardiac lipotoxicity exceed the increases in the rate of oxidation, which ev”
Chemistry in living systems (2005, background): “and, in recent years, have also been implicated in transcriptional regulatio”