Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9

By Dong Niu, Hongjiang Wei, Lin Lin, Haydy George, Tao Wang, I-Hsiu Lee, Hong-Ye Zhao, Yong Wang, Yinan Kan, Ellen L. Shrock and 11 more. Science, 2017

684 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/207c63fcf9c5d2cbed69043c13e9eb9ee9e30c42

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Jennifer A. Doudna

In Molecular Biology

1. Joy Y. Wang
2. Jennifer A. Doudna
3. Feng Zhang
4. Lei S. Qi
5. Rodolphe Barrangou

Citations in the corpus

• Importance of the pig as a human biomedical model (2021, methodology): “B. Zhang, C. Wang, Y. Zhang, Y. Jiang, Y. Qin, D. Pang, G. Zhang, H. Liu, Z. Xie, H. Yuan, H. Ouyang, J. Wang, X. Tang, A CRISPR-engineered swine model of COL2A1 deficiency recapitulates altered early skeletal developmental defects in humans.”
• CRISPR technology: A decade of genome editing is only the beginning (2023, background): “One notable example is the use of multiplexed editing to generate porcine endogenous retrovirus-inactivated pigs, addressing a major safety concern of transplanting pig organs into humans (82).”