Wearable salivary uric acid mouthguard biosensor with integrated wireless electronics
By Jayoung Kim, Somayeh Imani, W. D. de Araujo, Julian Warchall, G. Valdés-Ramírez, T. Paixão, P. Mercier, Joseph Wang. Biosensors & bioelectronics, 2015
542 citations recorded by the source corpus.
This article demonstrates an instrumented mouthguard capable of non-invasively monitoring salivary uric acid (SUA) levels. The enzyme (uricase)-modified screen printed electrode system has been integrated onto a mouthguard platform along with anatomically-miniaturized instrumentation electronics featuring a potentiostat, microcontroller, and a Bluetooth Low Energy (BLE) transceiver. Unlike RFID-based biosensing systems, which require large proximal power sources, the developed platform enables real-time wireless transmission of the sensed information to standard smartphones, laptops, and other consumer electronics for on-demand processing, diagnostics, or storage. The mouthguard biosensor system offers high sensitivity, selectivity, and stability towards uric acid detection in human saliva, covering the concentration ranges for both healthy people and hyperuricemia patients. The new wireless mouthguard biosensor system is able to monitor SUA level in real-time and continuous fashion, and can be readily expanded to an array of sensors for different analytes to enable an attractive wearable monitoring system for diverse health and fitness applications.
Subfields: Biomedical Engineering, Electrical and Electronic Engineering, Physiology
View Paper: https://www.semanticscholar.org/paper/92c91965b201f6ed0943da4d94f5467b935a043e
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Citations in the corpus
- The Emergence of AI-Based Wearable Sensors for Digital Health Technology: A Review (2023, methodology): “Wearable saliva biosensors can have different configurations, such as a wireless mouthguard biosensor used by Kim et al. [156] to detect uric acid to prevent diseases such as hyperuricemia, gout, and Lesch–Nyhan syndrome.”
- Evolution of Wearable Devices with Real-Time Disease Monitoring for Personalized Healthcare (2019, background): “demonstrated an enzyme-based biosensor integrated mouthguard for detecting salivary uric and lactate [33,34].”
- Flexible, Stretchable Sensors for Wearable Health Monitoring: Sensing Mechanisms, Materials, Fabrication Strategies and Features (2018, methodology): “saliva with th h lp of mouthg ard d vices [101,109].”
- Recent Advances in Biosensor Technology for Potential Applications – An Overview (2016, methodology): “Some of the most-notable sensitive, real-time and portable amperometric electrochemical biosensors have been developed (Kim et al., 2015) for disease diagnosis using body fluids.”