Nanoparticle Uptake: The Phagocyte Problem

By Heather H Gustafson, Dolly Holt-Casper, D. Grainger, H. Ghandehari. Nano Today, 2015

1,237 citations recorded by the source corpus.

Phagocytes are key cellular participants determining important aspects of host exposure to nanomaterials, initiating clearance, biodistribution and the tenuous balance between host tolerance and adverse nanotoxicity. Macrophages in particular are believed to be among the first and primary cell types that process nanoparticles, mediating host inflammatory and immunological biological responses. These processes occur ubiquitously throughout tissues where nanomaterials are present, including the host mononuclear phagocytic system (MPS) residents in dedicated host filtration organs (i.e., liver, kidney spleen, and lung). Thus, to understand nanomaterials exposure risks it is critical to understand how nanomaterials are recognized, internalized, trafficked and distributed within diverse types of host macrophages and how possible cell-based reactions resulting from nanomaterial exposures further inflammatory host responses in vivo. This review focuses on describing macrophage-based initiation of downstream hallmark immunological and inflammatory processes resulting from phagocyte exposure to and internalization of nanomaterials.

Subfields: Immunology, Materials Chemistry

View Paper: https://www.semanticscholar.org/paper/92b8870dd5e14420f2b7f0a1e9b9c392bfbb03fd

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

1. Siddharth Patel
2. G. Sahay
3. Jeonghwan Kim
4. Marco Herrera
5. A. Mukherjee
6. A. Kabanov

Citations in the corpus

• Brief update on endocytosis of nanomedicines (2019, background): “This affinity of macrophages to mannose can also be employed to deliver cargos targeting the immune system, such as antigens and immunostimulants [158,161,160].”