Biological effectiveness on live cells of laser driven protons at dose rates exceeding 109 Gy/s

By D. Doria, K. Kakolee, S. Kar, S. Litt, F. Fiorini, H. Ahmed, S. Green, J. Jeynes, J. Kavanagh, D. Kirby and 9 more. 2012

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The ultrashort duration of laser-driven multi-MeV ion bursts offers the possibility of radiobiological studies at extremely high dose rates. Employing the TARANIS Terawatt laser at Queen's University, the effect of proton irradiation at MeV-range energies on live cells has been investigated at dose rates exceeding 109 Gy/s as a single exposure. A clonogenic assay showed consistent lethal effects on V-79 live cells, which, even at these dose rates, appear to be in line with previously published results employing conventional sources. A Relative Biological Effectiveness (RBE) of 1.4±0.2 at 10% survival is estimated from a comparison with a 225 kVp X-ray source.

Subfields: Mechanics of Materials, Nuclear and High Energy Physics, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/928c81d3c7aab91b5abec3e3de35e8f878f766d5