American Heart Association/American College of Cardiology Foundation guide to warfarin therapy.
By J. Hirsh, Valentin Fuster, J. Ansell, J. Halperin. Journal of the American College of Cardiology, 2003
893 citations recorded by the source corpus.
Subfields: Cardiology and Cardiovascular Medicine, Surgery
View Paper: https://www.semanticscholar.org/paper/926fb5c753a820bed18f6f0b8352fdc19906bd39
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Citations in the corpus
- Safety, pharmacodynamics, and pharmacokinetics of single doses of BAY 59‐7939, an oral, direct factor Xa inhibitor (2005, background): “Orally administered warfarin inhibits the functional synthesis of the serine protease thrombin and several clotting factors, including factors VII, IX, and X, by interfering with the vitamin K–mediated carboxylation of their precursors”
- Safety, pharmacodynamics, and pharmacokinetics of BAY 59-7939—an oral, direct Factor Xa inhibitor—after multiple dosing in healthy male subjects (2005, background): “Vitamin K antagonists are currently the only anticoagulants indicated for long-term prevention of thromboembolic events in high-risk patients and are administrated orally; however, these drugs require frequent patient monitoring because of their unpredictable pharmacokinetics, narrow therapeutic win”
- Systematic overview of warfarin and its drug and food interactions. (2005, background): “The pharmacodynamics of warfarin may be influenced by medications that affect either vitamin K or the coagulation factors.(237) Sudden changes in dietary sources of vitamin K such as leafy greens or a supplemented diet followed by a change in warfarin’s effect are relatively easy to understand.”
- Comparison of outcomes among patients randomized to warfarin therapy according to anticoagulant control: results from SPORTIF III and V. (2007, background): “However, warfarin therapy has several drawbacks, including the requirement of close coagulation monitoring of the international normalized ratio (INR) and interactions with various foods and drugs.(2) Subtherapeutic intensities of anticoagulation can lead to a high stroke risk, and excessive anticoa”