Glial reactions in Parkinson's disease

By P. Mcgeer, E. Mcgeer. Movement Disorders, 2008

710 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/923673eff943ab741099f368cf8ec1bba4771ecd

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In Cellular and Molecular Neuroscience

In Neurology

Citations in the corpus

Animal models of Parkinson's disease: a source of novel treatments and clues to the cause of the disease (2011, background): “…to a reactive microgliosis that can persist long after toxin administration and that has been suggested to reflect an on-going loss of dopaminergic neurons that also occurred in MPTP exposed drug addicts (Langston et al., 1999; McGeer et al., 2003; Barcia et al., 2004; McGeer and McGeer, 2008).”
Past, Present, and Future of Parkinson’s Disease: A Special Essay on the 200th Anniversary of the Shaking Palsy (2017, positive): “Postmortem studies of the PD brain and PD model systems consistently demonstrate striking microglial activation.(259) This activation can also drive adaptive immune responses, including T cell infiltration, production of immunoglobins, and modifications of circulating myeloid cell populations, all o”
A Nurr1/CoREST transrepression pathway attenuates neurotoxic inflammation in activated microglia and astrocytes (2009, positive): “Although the etiologies of most common forms of PD remain poorly understood, the disease is generally associated with an inflammatory component that is manifested in part by the presence of activated microglia (central nervous system-resident macrophages) and elevated serum or cerebrospinal fluid le”
Mechanisms Underlying Inflammation in Neurodegeneration (2010, neutral): “Although these patients may have had further access to other drugs in the meantime, 18-year-old nonhuman primates given MPTP years earlier also exhibited activated microglia and dopaminergic neuronal loss in the absence of Lewy bodies, suggesting a long-lasting and self-driven reactive microgliosis ”
Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets (2023, background): “Remarkably, reactive M1 microglia were found several years after MPTP exposure in humans and non-human primates exposed to MPTP, indicating a long-lasting reactive microgliosis.(233) In rats, 6-OHDA injection also causes reactive microgliosis, which precedes astrogliosis and Fig.”
Hallmarks of neurodegenerative diseases. (2023, neutral): “Neuroinﬂammation, including microgliosis and astrogliosis, is a pathological hallmark of NDDs, including AD, PD, ALS, HD, and stroke 37,38,40,110,183,226,227 (Figures 1 and 3).”
Astrocytes: biology and pathology (2009, background): “The role of astrocytes in Parkinson’s disease and related syndromes is sparsely investigated and poorly understood [140].”
Alternatively activated microglia and macrophages in the central nervous system. (2015, background): “For instance, one of the oteins frequently associated to Parkinson’s disease pathology, anuclein, may lead to inflammation (see McGeer and McGeer, 08 for review).”