Spotlight on the Replisome: Aetiology of DNA Replication-Associated Genetic Diseases.

By R. Bellelli, S. Boulton. 2020

54 citations recorded by the source corpus.

Human development and tissue homeostasis depend on the regulated control of cellular proliferation and differentiation. DNA replication is essential to couple genome duplication and cell division with the establishment and maintenance of cellular differentiation programs. In eukaryotes, DNA replication is performed by a large machine known as the 'replisome,' which is strictly regulated in a cell cycle-dependent manner. Inherited mutations of replisome components have been identified in a range of genetic conditions characterised by developmental abnormalities and reduced organismal growth in addition to an involvement of the immune and endocrine systems and/or heightened tumour predisposition. Here, we review the current knowledge of the molecular genetics of replisome dysfunction disorders and discuss recent mechanistic insights into their pathogenesis, with a focus on the specific steps of DNA replication affected in these human diseases.

Subfields: Genetics, Molecular Biology

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In Molecular Biology

1. Johannes C. Walter
2. Masato T. Kanemaki
3. Sachiko Muramatsu

Citations in the corpus

• In silico protein interaction screening uncovers DONSON’s role in replication initiation (2023, background): “Meier-Gorlin syndrome (MGS), defined by growth restriction, microtia, and patella agenesis (49), is a form of microcephalic dwarfism specifically associated with genes encoding replication initiation factors (22).”