Lab-on-a-chip devices
By Y. Temiz, R. Lovchik, G. Kaigala, Emmanuel Delamarche. 2015
367 citations recorded by the source corpus.
Display Omitted We review two main challenges of microfluidics technology: sealing and interfacing.These are crucial for commercialization and wide-spread use of microfluidics.We review well-established techniques as well as recent state-of-the-art methods.We discuss both research and commercial activities.We provide up-to-date examples for each technology discussed. Lab-on-a-chip (LOC) devices are broadly used for research in the life sciences and diagnostics and represent a very fast moving field. LOC devices are designed, prototyped and assembled using numerous strategies and materials but some fundamental trends are that these devices typically need to be (1) sealed, (2) supplied with liquids, reagents and samples, and (3) often interconnected with electrical or microelectronic components. In general, closing and connecting to the outside world these miniature labs remain a challenge irrespectively of the type of application pursued. Here, we review methods for sealing and connecting LOC devices using standard approaches as well as recent state-of-the-art methods. This review provides easy-to-understand examples and targets the microtechnology/engineering community as well as researchers in the life sciences.
Subfields: Biomedical Engineering, Electrical and Electronic Engineering
View Paper: https://www.semanticscholar.org/paper/91ecaa6ee040bb1e6ba5fcc848f3c2dc86f0c359
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In Biomedical Engineering
Citations in the corpus
- Active Particles in Complex and Crowded Environments (2016, background): “On the other hand, understanding how to control the motion of artificial active particles through their interaction with complex environments could prove beneficial also for applications, e.g. inside lab-on-a-chip devices or living organisms (Chin et al., 2007).”
- High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue (2020, positive): “…was attached to the tissue section glass slides and a custom-designed acrylic clamp was used to firmly hold the PDMS against the tissue specimen to prevent leakage across microfluidic channels without the need for harsh bonding processed such as thermal bonding or plasma bonding (Temiz et al., 2015).”