Mapping complex disease loci in whole-genome association studies

By C. Carlson, M. Eberle, Leonid Kruglyak, Deborah A. Nickerson. Nature, 2004

662 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/91ac8148eb38ea1fea41694e2ed6116463d0cbba

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In Genetics

Citations in the corpus

Linkage disequilibrium levels in Bos indicus and Bos taurus cattle using medium and high density SNP chip data and different minor allele frequency distributions (2014, background): “Knowledge of the extent of LD in the genome is a necessary first step for determining the number of markers that will be sufficient to obtain sound results in GWAS (Goldstein, 2001; Carlson et al., 2004), QTL mapping by linkage disequilibrium (McKay et al.”
Genome-wide association studies for common diseases and complex traits (2005, background): “Association studies using common allelic variants are cheaper and simpler than the complete resequencing of candidate genes, and have been proposed as a powerful means of identifying the common variants that underlie complex trait”
Genetic dissection and prognostic modeling of overt stroke in sickle cell anemia (2005, background): “Genetic dissection of a complex trait requires disentangling the web of interactions among genes, environment and phenotyp”
Efficiency and power in genetic association studies (2005, background): “Although routine sequencing of thousands of genomes remains impractical, it has become possible to test systematically most human heterozygosity that is due to common genetic variation”
Association mapping of quality traits in potato (Solanum tuberosum L.) (2008, methodology): “association mapping methodology was developed and where successes were achieved (Carlson et al. 2004; Jorde 2000; Lander and Schork 1994).”
Epistasis—the essential role of gene interactions in the structure and evolution of genetic systems (2008, background): “Any suggestions to limit testing to only those QTLs with significant main effect”
The linkage disequilibrium and the selection of genetic markers for association studies in European populations (2007, background): “Their advantage is that the number of common coding SNPs (cSNPs) is several orders of magnitude smaller than the number of common SNPs overall (Carlson et al. 2004a).”
Association Mapping of Kernel Size and Milling Quality in Wheat (Triticum aestivum L.) Cultivars (2006, background): “…from the presence of alleles at different frequencies; and (iii) a serious multiple-testing problem, aggravated by the relative independence among testing positions, compared to populations with greater LD, which results in extremely strict genome-wise significance thresholds (Carlson et al. 2004).”
Genome-wide strategies for detecting multiple loci that influence complex diseases (2005, methodology): “This approach differs from those that require that single loci meet strict statistical significance in the first stag”
Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3 (2011, methodology): “Array-based genome-wide SNP association analyses should provide a more comprehensive, unbiased approach to detect susceptibility genes for diseases like PCO”