Estrogenic potency of chemicals detected in sewage treatment plant effluents as determined by in vivo assays with Japanese medaka (Oryzias latipes)

By C. Metcalfe, T. Metcalfe, Y. Kiparissis, B. Koenig, C. Khan, R. Hughes, T. Croley, R. March, Thomas Potter. Environmental Toxicology and Chemistry, 2001

618 citations recorded by the source corpus.

Subfields: Health, Toxicology and Mutagenesis, Physiology, Pollution

View Paper: https://www.semanticscholar.org/paper/916cfa763aea0937b93ca3b6daffeb7b08c469fe

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In Physiology

1. Manfred Schartl
2. Joachim Wittbrodt
3. G. Maack
4. A. Shima
5. V. Blazer

In Pollution

1. W. Kloas

Citations in the corpus

• Long-Term Exposure to Environmental Concentrations of the Pharmaceutical Ethynylestradiol Causes Reproductive Failure in Fish (2004, background): “…all relevant life stages and developmental end points; even where fish have been exposed over their whole life-cycle, the impact of any resulting reproductive dysfunction on their reproductive output has mostly been overlooked in earlier studies (Metcalfe et al. 2001; Van den Belt et al. 2003).”
• Determination of bisphenol A concentrations in human biological fluids reveals significant early prenatal exposure. (2002, background): “…have detected low dose effects of BPA in mice (Nagel et al., 1997; vom Saal et al., 1998; Gupta, 2000; Markey et al., 2001), rats (Steinmetz et al., 1997; Ramos et al., 2001), fish (Lindholst et al., 2000; Metcalfe et al., 2001), snails (Oehlmann et al., 2000), and frogs (Kloas et al., 1999).”
• Medaka — a model organism from the far east (2002, methodology): “and for testing ENDOCRINE DISRUPTORS in ecotoxicolog”
• Predicted Exposures to Steroid Estrogens in U.K. Rivers Correlate with Widespread Sexual Disruption in Wild Fish Populations (2005, background): “…for the induction of intersex were also taken from in vivo studies on medaka (Oryzias latipes), as they are the most conclusive studies for the suite of steroid estogens of interest in which the exposure concentrations of the three steroids were measured (Balch et al. 2004; Metcalfe et al. 2001).”
• A Weight of Evidence Approach to the Aquatic Hazard Assessment of Bisphenoi A (2002, background): “No skewing of sex ratio was observed by Metcalfe et al. (2001) in a 100-day test with medaka fish exposed to BPA at 120 µg/L.”
• A critical analysis of the biological impacts of plasticizers on wildlife (2009, background): “Similarly, exposure of medaka to concentrations up to 5 mg DEHP l21 for 90 days post-hatch did not affect germ cell development (Metcalfe et al. 2001).”