Critical aspects of the Bayesian approach to phase I cancer trials

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Phase 1 study of single-agent WNT974, a first-in-class Porcupine inhibitor, in patients with advanced solid tumours (2021, methodology): “Dosing decisions were guided by the escalation with the overdose control principle.(18,19) A dose was used for newly enrolled patients only if the risk of excessive toxicity at that dose was <25%; dose selection was also guided by all available toxicity, pharmacokinetic, and pharmacodynamic data.”
Biased sampling, over-identified parameter problems and beyond (2017, methodology): “In particular, the Bayesian logistic regression method (Neuenschwander, Branson, and Gsponer 2008) is one of the most commonly used designs in the pharmaceutical industry, and providing it would give the reader a taste of currently employed methods.”