Mediator and the mechanism of transcriptional activation.

By R. Kornberg. TIBS -Trends in Biochemical Sciences. Regular ed, 2005

608 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/90e72bd73d612c5845770ad3c60b0e0feb32cbb7

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In Molecular Biology

Citations in the corpus

The General Transcription Machinery and General Cofactors (2006, background): “In addition to TFIID, Mediator represents the second class of general cofactors that transmit the regulatory signals from gene-specific transcription factors to the general transcription machinery (Björklund and Gustafsson, 2005; Kornberg, 2005).”
Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes (2013, unknown): “…of enhancer-bound transcription factors to recruit RNA Pol II to the promoters of target genes (Borggrefe and Yue, 2011; Conaway and Conaway, 2011; Kornberg, 2005; Malik and Roeder, 2010) and is essential for maintenance of ESC state and embryonic development (Ito et al., 2000; Kagey et al.,…”
Architectural protein subclasses shape 3D organization of genomes during lineage commitment. (2013, unknown): “Although traditionally considered an adaptor protein with multiple subunits essential for transcriptional activation (Kornberg, 2005; Malik and Roeder, 2000), we suggest that the widespread enrichment in 3D interactions predicts a similar architectural role for Mediator.”
Transcriptional Regulation and its Misregulation in Disease (2013, unknown): “…signaling pathways and other regulators during transcription initiation and during the switch to elongation (Berk, 2012; Borggrefe and Yue, 2011; Conaway and Conaway, 2011; Kagey et al., 2010; Kornberg, 2005; Lariviere et al., 2012; Malik and Roeder, 2010; Spaeth et al., 2011; Taatjes, 2010).”
Mediator and RNA polymerase II clusters associate in transcription-dependent condensates (2018, background): “A conventional view of eukaryotic gene regulation is that transcription factors, bound to enhancer DNA elements, recruit coactivators such as the Mediator complex, which is thought to interact with RNA Polymerase II (Pol II) at the promoter (1-5).”
The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation (2010, methodology): “Following its biochemical isolation from yeast and metazoan cell”
Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers (2013, methodology): “…enhancer elements because enhancerbound transcription factors bind directly to Mediator (Borggrefe and Yue, 2011; Conaway and Conaway, 2011; Kornberg, 2005; Malik and Roeder, 2010; Taatjes, 2010) and because it has proven to produce high-quality evidence for enhancers in mammalian cells…”
Cooperative Regulation of Flavonoid and Lignin Biosynthesis in Plants (2021, background): “As a transcriptional regulatory center, mediator complex is a highly conservative and indispensable part of the eukaryotic transcription mechanism mediated by RNA polymerase II (Myers and Kornberg, 2000; Conaway et al., 2005; Kornberg, 2005; Malik and Roeder, 2010).”
β-Catenin hits chromatin: regulation of Wnt target gene activation (2009, background): “The evolutionarily conserved Mediator is a modular protein complex of approximately 30 subunits that relays the presence of transcription activators to the PI”