Evaluation of a new definition for chronic Pseudomonas aeruginosa infection in cystic fibrosis patients.

By Tim W.R. Lee, K. Brownlee, S. Conway, M. Denton, J. Littlewood. Journal of Cystic Fibrosis, 2003

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Pseudomonas aeruginosa: resistance and therapeutic options at the turn of the new millennium. (2007, background): “The definition of chronic colonisation is still a matter of debate [138,139], but there is no doubt that this state has a major negative impact on the patient’s prognosis, as it is associated with an accelerated decline of respiratory function (forced expiratory volume in 1 s (FEV1)) [140–142], shor”
The bronchiectasis severity index. An international derivation and validation study. (2014, positive): “Chronic colonization was defined by the isolation of potentially pathogenic bacteria in sputum culture on two or more occasions, at least 3 months apart in a 1-year period (14, 16, 17).”