Apoptosis: a basic biological phenomenon with wide‐ranging implications in human disease

By Bengt Fadeel, S. Orrenius. Journal of Internal Medicine, 2005

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From pyroptosis, apoptosis and necroptosis to PANoptosis: A mechanistic compendium of programmed cell death pathways (2021, background): “Based on morphological examinations and the DNA fragmentation status of dead cells, cell death was initially classiﬁed as ‘‘programmed” apoptosis [2] and ‘‘accidental” necrosis [3] in mammalian cells.”
DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy (2021, background): “In 1972, apoptosis was defined, which is a programmed cell death pathway occurring in cells during the normal tissue development or encountering exogenous stresses, especially DNA damage.(139,140) In 1981, the concept of oncogenes was introduced,(141) followed by the concept of tumor suppressors thr”
Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma. (2005, background): “Page 12 extrinsic pathway mediated by activation of Fas/caspase-8-dependent signaling, which then converge on a common effector, caspase-3.(22) Bortezomib-induced apoptosis activates both pathways,(23) and we therefore examined whether carfilzomib had similar pro-apoptotic effects.”