Regulation of Oxidative Stress by the Anti-aging Hormone Klotho*♦
By Masaya Yamamoto, Jeremy D. Clark, J. Pastor, Prem Gurnani, A. Nandi, H. Kurosu, Masayoshi Miyoshi, Y. Ogawa, D. Castrillon, K. Rosenblatt and 1 more. Journal of Biological Chemistry, 2005
704 citations recorded by the source corpus.
klotho is an aging suppressor gene and extends life span when overexpressed in mice. Klotho protein was recently demonstrated to function as a hormone that inhibits insulin/insulin-like growth factor-1 (IGF-1) signaling. Here we show that Klotho protein increases resistance to oxidative stress at the cellular and organismal level in mammals. Klotho protein activates the FoxO forkhead transcription factors that are negatively regulated by insulin/IGF-1 signaling, thereby inducing expression of manganese superoxide dismutase. This in turn facilitates removal of reactive oxygen species and confers oxidative stress resistance. Thus, Klotho-induced inhibition of insulin/IGF-1 signaling is associated with increased resistance to oxidative stress, which potentially contributes to the anti-aging properties of klotho.
Subfields: Genetics, Molecular Biology, Nephrology
View Paper: https://www.semanticscholar.org/paper/907cd4f40fc33c6c8b490786e2ff957466037102
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Genetics
In Molecular Biology
In Nephrology
Citations in the corpus
- Research resource: Comprehensive expression atlas of the fibroblast growth factor system in adult mouse. (2010, background): “Disruption of the Klotho gene causes a premature aging phenotype (12), whereas transgenic mice that overexpress Klotho exhibit increased resistance to oxidative stress (13) and a significant extension of lifespan (14).”
- Programming the magnitude and persistence of antibody responses with innate immunity (2011, neutral): “vector RIG 0 2 4 6 vector KLm (1-1012) KLs (1-549) KLsss (34-549)”