Advancing the speed, sensitivity and accuracy of biomolecular detection using multi-length-scale engineering

By S. Kelley, Chad A. Mirkin, D. Walt, R. Ismagilov, Mehmet Toner, Edward H. Sargent. Nature Nanotechnology, 2014

352 citations recorded by the source corpus.

Rapid progress in identifying disease biomarkers has increased the importance of creating high-performance detection technologies. Over the last decade, the design of many detection platforms has focused on either the nano or micro length scale. Here, we review recent strategies that combine nano- and microscale materials and devices to produce large improvements in detection sensitivity, speed and accuracy, allowing previously undetectable biomarkers to be identified in clinical samples. Microsensors that incorporate nanoscale features can now rapidly detect disease-related nucleic acids expressed in patient samples. New microdevices that separate large clinical samples into nanocompartments allow precise quantitation of analytes, and microfluidic systems that utilize nanoscale binding events can detect rare cancer cells in the bloodstream more accurately than before. These advances will lead to faster and more reliable clinical diagnostic devices.

Subfields: Biomedical Engineering, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/9046b2f4fff78ea7b25a57756abde93307a08d21

Citations in the corpus

• SERS based point-of-care detection of food-borne pathogens (2016, neutral): “ELISA based techniques are highly sensitive with detection limits as low as tens of picograms of protein per milliliter of sample [16].”