Burden of Disease Caused by Otitis Media: Systematic Review and Global Estimates
By L. Monasta, L. Ronfani, F. Marchetti, M. Montico, L. Vecchi Brumatti, A. Bavcar, D. Grasso, Chiara Barbiero, G. Tamburlini. PLoS ONE, 2012
1,052 citations recorded by the source corpus.
Background Otitis media (OM) is a leading cause of health care visits and drugs prescription. Its complications and sequelae are important causes of preventable hearing loss, particularly in developing countries. Within the Global Burden of Diseases, Injuries, and Risk Factors Study, for the year 2005 we estimated the incidence of acute OM, chronic suppurative OM, and related hearing loss and mortality for all ages and the 21 WHO regional areas. Methods We identified risk factors, complications and sequelae of OM. We carried out an extensive literature review (Medline, Embase, Lilacs and Wholis) which lead to the selection of 114 papers comprising relevant data. Data were available from 15 of the 21 WHO regions. To estimate incidence and prevalence for all countries we adopted a two stage approach based on risk factors formulas and regression modelling. Results Acute OM incidence rate is 10.85% i.e. 709million cases each year with 51% of these occurring in under-fives. Chronic suppurative OM incidence rate is 4.76‰ i.e. 31million cases, with 22.6% of cases occurring annually in under-fives. OM-related hearing impairment has a prevalence of 30.82 per ten-thousand. Each year 21thousand people die due to complications of OM. Conclusions Our study is the first attempt to systematically review the available information and provide global estimates for OM and related conditions. The overall burden deriving from AOM, CSOM and their sequelae is considerable, particularly in the first five years of life and in the poorest countries. The findings call for incorporating OM-focused action within preventive and case management strategies, with emphasis on the more affected.
Subfields: Cognitive Neuroscience, Otorhinolaryngology, Sensory Systems
View Paper: https://www.semanticscholar.org/paper/8ff81624f7c96f8fbbb6ef4bc13f06409fed49f9
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Citations in the corpus
- IL‐12 and IL‐7 synergize to control mucosal‐associated invariant T‐cell cytotoxic responses to bacterial infection (2017, background): “This obligate human pathogen is a leading cause of respiratory infections in the 89 very young and elderly and is associated with a range of clinically important infections 90 including acute otitis media, pneumonia and bacteraemia [13][14].”
- Clinical Practice Guideline: Otitis Media with Effusion (Update) (2016, background): “OME is the most common cause of hearing impairment in children in developed nations,(29) and permanent hearing loss related to otitis media has a prevalence of 2 to 35 per 10,000.(30) Otitis media may be related to difficulties in speech and reading, delayed response to auditory input, limited vocab”
- Bacterial Biofilm and its Role in the Pathogenesis of Disease (2020, background): “These conditions can lead to temporary or permanent hearing loss [11].”