Wound healing, fibroblast heterogeneity, and fibrosis

By Heather E. Talbott, Shamik Mascharak, M. Griffin, D. Wan, M. Longaker. Cell Stem Cell, 2022

674 citations recorded by the source corpus.

Fibroblasts are highly dynamic cells that play a central role in tissue repair and fibrosis. However, the mechanisms by which they contribute to both physiologic and pathologic states of extracellular matrix deposition and remodeling are just starting to be understood. In this review article, we discuss the current state of knowledge in fibroblast biology and heterogeneity, with a primary focus on the role of fibroblasts in skin wound repair. We also consider emerging techniques in the field, which enable an increasingly nuanced and contextualized understanding of these complex systems, and evaluate limitations of existing methodologies and knowledge. Collectively, this review spotlights a diverse body of research examining an often-overlooked cell type - the fibroblast - and its critical functions in wound repair and beyond.

Subfields: Genetics, Rehabilitation, Surgery

View Paper: https://www.semanticscholar.org/paper/8fb0790df024ed58e3abfc38a64d4e1846a6bb03

Citations in the corpus

• Cellular and molecular mechanisms of skin wound healing (2024, neutral): “New mathematical tools are enabling ‘trajectory’ reporting of cell fates and behaviours over time and the linking of multi-omics analyses from the same cells, particularly of wound fibroblasts 236,237 .”