HSP90 at the hub of protein homeostasis: emerging mechanistic insights

By Mikko Taipale, Daniel F. Jarosz, Susan Lindquist. Nature reviews. Molecular cell biology, 2010

1,826 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/0a00a0db69784713e58e42601d6e826b8bba4144

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Citations in the corpus

Molecular chaperones in protein folding and proteostasis (2011, background): “The HSP90 system HSP90 forms a proteostasis hub that controls numerous important signalling pathways in eukaryotic cell”
Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition (2012, background): “clients) associate with HSP90 because the chaperone recognizes something related to their conformational instability, but the data are insufficient to reach any unifying conclusions and reconcile diverse observations (Caplan et al., 2007; Taipale et al., 2010).”
The Response to Heat Shock and Oxidative Stress in Saccharomyces cerevisiae (2012, background): “As with Hsp70, Hsp90 is an ATP binding protein whose chaperone cycle is governed by nucleotide cycling (see Taipale et al. 2010).”
The heat shock response: life on the verge of death. (2010, background): “…in prokaryotes to the most sophisticated chaperone machinery known in eukaryotes, working together with a large cohort of cochaperones that associate in a defined order during the chaperone cycle (Figure 3) (Pearl and Prodromou, 2006; Taipale et al., 2010; Wandinger et al., 2008; Li et al., 2010).”
SMYD2-dependent HSP90 methylation promotes cancer cell proliferation by regulating the chaperone complex formation. (2014, background): “293T cells were co-transfected with a FLAGSMYD2 expression vector and four different lengths of HA-HSP90AB1 vectors ([1–724], [1–500], [250–724] and [500–724]).”
The plant heat stress transcription factor (Hsf) family: structure, function and evolution. (2012, background): “With thediscovery thatmembers of theHsp families act asmolecular chaperones involved in many aspects of protein homeostasis and cell signaling ([153]; see Introduction), the central concept of HS signaling always centered around the disruption of cytosolic protein homeostasis anddepletion of the poo”