PIFs: pivotal components in a cellular signaling hub
By P. Leivar, P. Quail. Trends in Plant Science, 2010
954 citations recorded by the source corpus.
A small subset of basic helix–loop–helix transcription factors called PIFs [phytochrome (phy)-interacting factors] act to repress seed germination, promote seedling skotomorphogenesis and promote shade-avoidance through regulated expression of over a thousand genes. Light-activated phy molecules directly reverse these activities by inducing rapid degradation of the PIF proteins. Here, we review recent advances in dissecting this signaling pathway and examine emerging evidence that indicates that other pathways also converge to regulate PIF activity, including the gibberellin pathway, the circadian clock and high temperature. The PIFs thus have broader roles than previously appreciated, functioning as a cellular signaling hub that integrates multiple signals to orchestrate regulation of the transcriptional network that drives multiple facets of downstream morphogenesis. The relative contributions of the individual PIFs to this spectrum of regulatory functions ranges from quantitatively redundant to qualitatively distinct.
Subfields: Molecular Biology, Plant Science
View Paper: https://www.semanticscholar.org/paper/8f171ad666ebd82d17d4000827c3e9d1964b6ffa
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Citations in the corpus
- Coordination of Cryptochrome and Phytochrome Signals in the Regulation of Plant Light Responses (2017, background): “Accordingly, recent analyses have revealed that crys and phys share two common signaling pathways, and they both bind with the COP1/SUPPRESSOR OF PHYA-105 (SPA) complex, which targets certain sets of transcription factors for degradation [77–81], and a subset of bHLH transcription factors, PHYTOCHRO”
- Shade Avoidance (2012, neutral): “basic helix–loop–helix transcription factors that bind the active form of phyB (some also bind phyA) in the nucleus and as a result of this interaction become rapidly phosphorylated, apparently ubiquitylated and finally degraded in the proteasome (Leivar and Quail, 2011).”
- Comprehending crystalline β-carotene accumulation by comparing engineered cell models and the natural carotenoid-rich system of citrus (2011, neutral): “It”
- Antioxidants and Antioxidant Enzymes in Higher Plants (2018, background): “PIFq and HY5 act antagonistically for a broad set of responses (Kami et al. 2010; Lau and Deng 2010; Leivar and Quail 2011; Chen et al. 2013), including the control of PSY expression and carotenoid biosynthesis (Toledo-Ortiz et al. 2010, 2014).”
- PHYTOCHROME-INTERACTING FACTOR 4 (PIF4) regulates auxin biosynthesis at high temperature (2011, background): “Plants were grown at 12 °C for 7 d (12) or at 12 °C for 5 d then at 27 °C for 48 h (27).”