Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development.
By N. Gale, M. Dominguez, I. Noguera, Li Pan, Virginia C. Hughes, D. Valenzuela, A. Murphy, N. Adams, H. Lin, J. Holash and 2 more. Proceedings of the National Academy of Sciences of the United States of America, 2004
635 citations recorded by the source corpus.
Subfields: Molecular Biology
View Paper: https://www.semanticscholar.org/paper/8ea97804ea9640e355b71f2f028abe088446bf5e
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In Molecular Biology
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- Janet Rossant
Citations in the corpus
- Endothelial cells and VEGF in vascular development (2005, background): “However, mutations in Dll4, which is a Notch ligand specifically expressed in developing arterial but not venous endothelium, lead to defective development of the dorsal aorta and cardinal veins, with development of arterio-venous shunt”
- The control of vascular integrity by endothelial cell junctions: molecular basis and pathological implications. (2009, background): “, 2000), Notch ligand Dll4 (Duarte et al., 2004; Gale et al., 2004; Krebs et al., 2004), Notch effector Rbpj and Mib, and Hey1/Hey2 double mutants (Fischer et al.”
- Notch signalling in vertebrate neural development (2006, background): “Development is extraordinarily sensitive to the dosage of Notch signalling, as has been revealed by various studies involving different expression levels of Notch pathway element”