Progress and potential in organoid research
By Giuliana Rossi, Andrea Manfrin, M. Lutolf. Nature reviews genetics, 2018
1,000 citations recorded by the source corpus.
Tissue and organ biology are very challenging to study in mammals, and progress can be hindered, particularly in humans, by sample accessibility and ethical concerns. However, advances in stem cell culture have made it possible to derive in vitro 3D tissues called organoids, which capture some of the key multicellular, anatomical and even functional hallmarks of real organs at the micrometre to millimetre scale. Recent studies have demonstrated that organoids can be used to model organ development and disease and have a wide range of applications in basic research, drug discovery and regenerative medicine. Researchers are now beginning to take inspiration from other fields, such as bioengineering, to generate organoids that are more physiologically relevant and more amenable to real-life applications. Organoids are 3D structures derived from stem cells that recapitulate some key characteristics of real organs. The authors review recent progress in organoid derivation and applications and outline how advances in other disciplines might lead to more physiologically relevant organoids.
Subfields: Biomedical Engineering, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/8e5200a8cef3d83b8ea464f894ec74884014cc99
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In Molecular Biology
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- ARTIFICIAL INTELLIGENCE AND PERSONALIZED MEDICINE (2019, background): “For example, emerging induced pluripotent stem cell (iPSC) and organoid technologies have shown great promise in yielding insights into patient-specific pathologies that could be overcome with specific interventions (see Table 2 of Schork and Nazor [6] as well as Rossi et al.[37]).”