Phagocytosis of apoptotic cells in homeostasis
By S. Arandjelovic, K. Ravichandran. Nature Immunology, 2015
807 citations recorded by the source corpus.
Human bodies collectively turn over about 200 billion to 300 billion cells every day. Such turnover is an integral part of embryonic and postnatal development, as well as routine tissue homeostasis. This process involves the induction of programmed cell death in specific cells within the tissues and the specific recognition and removal of dying cells by a clearance 'crew' composed of professional, non-professional and specialized phagocytes. In the past few years, considerable progress has been made in identifying many features of apoptotic cell clearance. Some of these new observations challenge the way dying cells themselves are viewed, as well as how healthy cells interact with and respond to dying cells. Here we focus on the homeostatic removal of apoptotic cells in tissues.
Subfields: Immunology, Physiology, Surgery
View Paper: https://www.semanticscholar.org/paper/8e3845d904ea2108567e1100d4e77f6e36428427
How researchers see this paper
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In Immunology
- T. Kanneganti
- R. Malireddi
- S. Kesavardhana
- S. Gordon
- J. Bentzon
- Alberico L. Catapano
- A. Mantovani
- TA Wynn
In Physiology
In Surgery
- I. Graham
- Jan Boren
- R. Malireddi
- S. Kesavardhana
- M. Chapman
- Marja-Riitta Taskinen
- Alberico L. Catapano
- S. Gordon
Citations in the corpus
- Caspases in Cell Death, Inflammation, and Gasdermin-Induced Pyroptosis (2020, background): “This in turn proteolytically activates effector caspases, which facilitate the systematic dismantling of cellular components, leading to characteristic intracellular changes including DNA degradation, nuclear shrinkage (pyknosis) and fragmentation (karyorrhexis), membrane blebbing, and release of ap”
- Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel (2020, background): “tosis, is an important homeostatic process that ensures resolution of inflammatory responses (Figure 4).(155,156) This involves recognition of”
- Phagocytosis: An Immunobiologic Process. (2016, background): “Many of these topics have been covered in excellent reviews, including in this issue of Immunity, and will be dealt with only in outline here (Arandjelovic and Ravichandran, 2015; Flannagan et al., 2012; Gordon, 2012).”