Pyroptosis: A new frontier in cancer.
By Yuan Fang, S. Tian, Yu-tian Pan, Wei Li, Qiming Wang, Yu Tang, Tao Yu, Xi Wu, Yongkang Shi, Pei Ma and 1 more. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019
878 citations recorded by the source corpus.
Pyroptosis is an inflammatory form of cell death triggered by certain inflammasomes, leading to the cleavage of gasdermin D (GSDMD) and activation of inactive cytokines like IL-18 and IL-1β. Pyroptosis has been reported to be closely associated to some diseases like atherosclerosis and diabetic nephropathy. Recently, some studies found that pyroptosis can influence the proliferation, invasion and metastasis of tumor, which regulated by some non-coding RNAs and other molecules. Hence, we provided an overview of morphological and molecular characteristics of pyroptosis. We also focus on mechanism of regulating pyroptosis in tumor cells as well as the potential roles of pyroptosis in cancer to explore potential diagnostic markers in cancers contributing to the prevention and treatment in cancers.
Subfields: Immunology, Molecular Biology, Nephrology
View Paper: https://www.semanticscholar.org/paper/8e33171ab4289b2fa0d43f891a18b4013460f1ff
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Citations in the corpus
- Ferroptosis in cancer: from molecular mechanisms to therapeutic strategies (2024, background): “4 Cells undergoing ferroptosis display distinct hallmarks compared to other extensively studied forms of RCD, 5 such as apoptosis, 6 pyroptosis, 7 and necroptosis.”
- Role of pyroptosis in inflammation and cancer (2022, background): “Inflammasomes are multimeric complexes composed of essential components, wherein they protect host cells against the assault of endogenous danger signals and some pathogens [29, 32].”
- Targeting cell death pathways for cancer therapy: recent developments in necroptosis, pyroptosis, ferroptosis, and cuproptosis research (2022, background): “Brief overview of cancer cell proliferation and metastasis Cell death is a physiological regulator of cell proliferation, and both processes exert profound effects on growth and development throughout life [48].”