Effects of different doses in continuous veno-venous haemofiltration on outcomes of acute renal failure: a prospective randomised trial.

By Claudio Ronco, R. Bellomo, P. Homel, A. Brendolan, M. Dan, P. Piccinni, G. Greca. The Lancet, 2000

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Acute renal failure – definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group (2004, methodology): “Patient survival (or its reciprocal, mortality) has commonly been used as the primary end-point in clinical trials of RRT in ARF, although the timing has varied [ 16-18 ].”
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016 (2017, background): “Two additional RCTs reporting the effect of dose of CRRT on outcomes in patients with acute renal failure were identified in the current literature review (504, 505).”
Effect of acute renal failure requiring renal replacement therapy on outcome in critically ill patients* (2002, background): “(32) showing that an increase in the hemofiltration dose improves outcome in a specific group of patients is a first step toward a better understanding of the optimal dose of extracorporeal therapy required in critically ill patients with ARF.”