Sensitivity of Human Immunodeficiency Virus Type 1 to the Fusion Inhibitor T-20 Is Modulated by Coreceptor Specificity Defined by the V3 Loop of gp120

By C. Derdeyn, J. Decker, Jeffrey N. Sfakianos, Xiaoyun Wu, W. O'brien, L. Ratner, J. Kappes, G. Shaw, E. Hunter. Journal of Virology, 2000

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HIV-1 antiretroviral drug therapy. (2012, background): “Nonetheless, studies of baseline susceptibility to enfuvirtide suggested that large variations in intrinsic susceptibility existed in diverse HIV-1 isolates, and that these variations mapped to regions outside the enfuvirtidebinding site (Derdeyn et al. 2000).”
RNA motif discovery by SHAPE and mutational profiling (SHAPE-MaP) (2014, neutral): “Viruses were measured for infectivity on TZM-bl indicator cells 53 (using Glo Lysis buffer and the Luciferase Assay System; Promega).”
Emergence of Resistant Human Immunodeficiency Virus Type 1 in Patients Receiving Fusion Inhibitor (T-20) Monotherapy (2002, background): “(6), these differences appear not to affect susceptibility to T-20.”