Delayed coupling to feedback inhibition during a critical period for the integration of adult-born granule cells

By Silvio G. Temprana, L. Mongiat, S. M. Yang, M. Trinchero, D. D. Alvarez, Emilio Kropff, Damiana Giacomini, N. Beltramone, G. Lanuza, A. F. Schinder. 2014

196 citations recorded by the source corpus.

SUMMARY Developing granule cells (GCs) of the adult dentate gyrus undergo a critical period of enhanced activity and synaptic plasticity before becoming mature. The impact of developing GCs on the activity of preexisting dentate circuits remains unknown. Here we combine optogenetics, acute slice electrophysiology, and in vivo chemogenetics to activate GCs at different stages of maturation to study the recruitment of local target networks. We show that immature (four-week-old) GCs can efficiently drive distal CA3 targets, but poorly activate proximal interneurons responsible for feedback inhibition (FBI). As new GCs transition towards maturity, they reliably recruit GABAergic feedback loops that restrict spiking of neighbor GCs, a mechanism that would promote sparse coding. Such inhibitory loop impinges only weakly in new cohorts of young GCs. A computational model reveals that the delayed coupling of new GCs to FBI could be crucial to achieve a fine-grain representation of novel inputs in the dentate gyrus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

In Developmental Neuroscience

Citations in the corpus

Re-evaluating circuit mechanisms underlying pattern separation (2019, positive): “Feedback inhibition adaptively regulates excitability (Hamann et al., 2002; Papadopoulou et al., 2011; Gupta and Stopfer 2012; Lin et al., 2014; Temprana et al., 2014; Kee et al., 2015), in part by matching spike threshold to the overall activity level (Mitchell and Silver, 2003; Billings et al.”
The role of adult hippocampal neurogenesis in brain health and disease (2018, background): “Giachino C, Barz M, Tchorz JS, Tome M, Gassmann M, Bischofberger J, et al. GABA suppresses neurogenesis in the adult hippocampus through GABAB receptors.”
Distinct Contribution of Adult-Born Hippocampal Granule Cells to Context Encoding (2016, unknown): “The broader tuning profile of abGCs (compared to mGCs) is consistent with computational models of GC dynamics andmight support the encoding of novel features in the environment (Aimone et al., 2011; Temprana et al., 2015).”
Adult Neurogenesis in the Hippocampus: From Stem Cells to Behavior. (2016, unknown): “…DG excitability; experiments in hippocampal slices suggest that immature adult-born neurons are poorly coupled to inhibitory neurons in the DG and hilus (Temprana et al., 2015) while being subject to feedback and feedforward inhibitory inputs themselves (Dieni et al., 2016; Li et al., 2012, 2013b).”