Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion

By J. P. Friedmann Angeli, D. Krysko, M. Conrad. Nature Reviews. Cancer, 2019

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Lipid Peroxidation and Iron Metabolism: Two Corner Stones in the Homeostasis Control of Ferroptosis (2022, background): “Various studies propose an important role of GPX4 in immunity and suggest that modulation of GPX4 expression in certain immune cells will affect antitumor immunity [80].”
Ferroptosis in cancer: from molecular mechanisms to therapeutic strategies (2024, background): “15,182 The radical-trapping antioxidant system mechanisms of ferroptosis, which are mediated by the FSP1 and GCH1, are also upregulated in some cancers and contribute to ferroptosis evasion and tumor development.”
Targeting cell death pathways for cancer therapy: recent developments in necroptosis, pyroptosis, ferroptosis, and cuproptosis research (2022, background): “Tumor ferroptosis alters the TME Ferroptotic cancer cells generate some “find-me” and “eat-me” immunostimulating signals, particularly DAMPs, which robustly recruit DCs, MΦs, and other immune cells properly to the site of dying tumor cells [192, 193].”