Phage Therapy: From Biologic Mechanisms to Future Directions

By S. Strathdee, Graham F. Hatfull, Vivek K. Mutalik, R. Schooley. Cell, 2023

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Increasing antimicrobial resistance rates have revitalized bacteriophage (phage) research, the natural predators of bacteria discovered over one hundred years ago. In order to use phages therapeutically, they should 1) preferably be lytic; 2) kill the bacterial host efficiently, 3) be fully characterized to exclude side effects. Developing therapeutic phages takes a coordinated effort of multiple stakeholders. Herein, we review the state of the art in phage therapy, covering biologic mechanisms, clinical applications, remaining challenges and future directions involving naturally occurring and genetically modified or synthetic phages.

Subfields: Ecology, Microbiology, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/8daa35bd0bc5806f1089ce67409c7fb085d5d83c