Cardiac-resynchronization therapy in heart failure with narrow QRS complexes.

By J. Beshai, R. Grimm, Sherif F. Nagueh, James Baker, S. Beau, S. Greenberg, L. Pires, P. Tchou. New England Journal of Medicine, 2007

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Current and evolving echocardiographic techniques for the quantitative evaluation of cardiac mechanics: ASE/EAE consensus statement on methodology and indications endorsed by the Japanese Society of Echocardiography. (2011, methodology): “It is clear that a number of factors should be taken into consideration, aside from mechanical dyssynchrony, in trying to predict the response to CRT.”
ACC/AHA/HRS 2008 Guidelines for device-based therapy of cardiac rhythm abnormalities. (2008, background): “did not confirm the utility of dyssynchrony evaluation by echocardiography to guide CRT implantation, especially when the QRS is not prolonged (226).”
ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012 (2012, background): “The possibility that patients with a QRS duration of ,120 ms may have ‘mechanical dyssynchrony’ (detectable by imaging) and might benefit from CRT is another area of research interest but remains to be proven.(159,160)”