How Fast-Folding Proteins Fold
By K. Lindorff‐Larsen, Stefano Piana, Ron O. Dror, David E. Shaw. Science, 2011
1,934 citations recorded by the source corpus.
Subfields: Materials Chemistry, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/8d69402910a9d34c2bf4be44e2dffbfb29a7c285
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In Materials Chemistry
- Yang Zhang
- Robin Pearce
- Michael Feig
- Frank No'e
- David Baker
- Lim Heo
- Sergey Ovchinnikov
- Ivan V. Anishchenko
In Molecular Biology
Citations in the corpus
- The future of molecular dynamics simulations in drug discovery (2011, methodology): “These folding results have been extended to encompass 12 small proteins of diverse structure— a -helical, b -sheet, and mixed a / b —with 8 of the 12 proteins reaching RMSD values less than 2 A˚ from the respective crystal structure [53].”
- Computational Methods in Drug Discovery (2014, methodology): “Anton has been used successfully for full atomic resolution protein folding (Lindorff-Larsen et al., 2011).”
- AlphaDesign: A de novo protein design framework based on AlphaFold (2021, positive): “…methods such as molecular dynamics (MD) simulations have provided a route to characterise the dynamics, thermodynamics and kinetics of conformational transitions [29, 30], ab initio folding [31], disordered transitions [32, 33] as well as protein-protein [34, 35] and protein-ligand [36] binding.”
- Assessment of the model refinement category in CASP12 (2017, background): “22 However, due to a combination of computationally prohibitive sampling times (especially in the context of CASP), missing information on structure-determining contacts (e.g., cofactors, ligands and protein-protein contacts) as well as residual force-field inaccuracies, refinement with MD…”
- Versatile sample environments and automation for biological solution X-ray scattering experiments at the P12 beamline (PETRA III, DESY) (2015, background): “The timescales for the experiments are broad, spanning from the submillisecond range for rapid protein folding events (Kathuria et al., 2011; Lindorff-Larsen et al., 2011) to hours for amyloid 436 Clement E. Blanchet et al. Versatile sample environments and automation J. Appl.”