Targeted disruption of hormone-sensitive lipase results in male sterility and adipocyte hypertrophy, but not in obesity.

By J. Osuga, Shu Ishibashi, Teruaki Oka, H. Yagyu, R. Tozawa, Akihisa Fujimoto, F. Shionoiri, N. Yahagi, F. Kraemer, O. Tsutsumi and 1 more. Proceedings of the National Academy of Sciences of the United States of America, 2000

598 citations recorded by the source corpus.

Subfields: Biochemistry, Physiology, Surgery

View Paper: https://www.semanticscholar.org/paper/8d66cf9f03bc8a8463fc78f76f09c486f3b507a3

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In Biochemistry

1. R. Zechner
2. Frank Madeo

In Physiology

1. R. Zechner
2. R. Zimmermann
3. J. Qin
4. A. Lass

Citations in the corpus

• ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1 (2011, background): “The relatively benign phenotype of Hsl deficiency in mice ( Hsl -knockout mice, hereafter referred to as Hsl KO) argues against a crucial role of this enzyme in the regulation of PPARs and energy homeostasi”
• Regulation of lipolysis in adipocytes. (2007, unknown): “On a normal chow diet, HSL-null mice had body weights similar to wild-type mice (47), and adipocyte size was reportedly either similar or slightly larger (94)—a finding that is consistent with a role for HSL in adipocyte FA mobilization.”
• Brummer lipase is an evolutionary conserved fat storage regulator in Drosophila. (2005, background): “However, HSL knockout mice are viable and not obese (Osuga et al., 2000), having substantial residual lipolytic activity (Okazaki et al., 2002).”
• Growth and Lipid Metabolism of the Pacific White Shrimp Litopenaeus vannamei at Different Salinities (2014, background): “…mobilization has increased, because ATGL (TAG hydrolysis), LPL, and HSL are crucial enzymes in lipid mobilization by performing the first step in hydrolyzing TAG to generate diacylglycerol and free fatty acid (Osuga et al. 2000, Jenkins et al. 2004, Villena et al. 2004, Zimmermann et al. 2004).”
• Lipolysis – A highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores (2011, background): “In contrast to ATGL deficiency, hormone-sensitive lipase (HSL)deficient mice do not show increased fat deposition, are not overweight or obese, and lose WAT mass with increasing age [11,12,19,20].”