Aptamers: Problems, Solutions and Prospects

By A. V. Lakhin, V. Tarantul, L. Gening. Acta Naturae, 2013

455 citations recorded by the source corpus.

Aptamers are short single-stranded oligonucleotides that are capable of binding various molecules with high affinity and specificity. When the technology of aptamer selection was developed almost a quarter of a century ago, a suggestion was immediately put forward that it might be a revolutionary start into solving many problems associated with diagnostics and the therapy of diseases. However, multiple attempts to use aptamers in practice, although sometimes successful, have been generally much less efficient than had been expected initially. This review is mostly devoted not to the successful use of aptamers but to the problems impeding the widespread application of aptamers in diagnostics and therapy, as well as to approaches that could considerably expand the range of aptamer application.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8d41d256ede87fd49fc26a781f08e3aa24b175f4

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Citations in the corpus

• Electrochemical biosensors for pathogen detection (2020, background): “However, the use of aptamers as biorecognition elements has not yet replaced traditional biorecognition elements, such as antibodies, because of several challenges, such as aptamer stability, degradation, cross-reactivity, and reproducibility using alternative processing approaches (Lakhin et al. 20”