Activation of synaptic NMDA receptors induces membrane insertion of new AMPA receptors and LTP in cultured hippocampal neurons.

By Wei-yang Lu, H. Man, W. Ju, W. Trimble, J. Macdonald, Yu Tian Wang. Neuron, 2001

974 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8d3e21d2a3baded8d1f106103456484ea3be34b1

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Citations in the corpus

The cell biology of synaptic plasticity: AMPA receptor trafficking. (2007, background): “However, these data are inconsistent with many studies, including data from the same laboratory (Lu et al. 2001), that find more rapid insertion of receptors into the plasma membrane at dendrites and synapses.”
Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome system (2003, methodology): “Synaptic NMDA receptors were selectively activated using a previously described glycine application metho”
Long-term potentiation and memory. (2004, background): “As a consequence of the depolarization, calcium influx through NMDA receptor-associated channels occurs, amygdalar neurons fire action potentials which back-propagate into the dendrites, and this coincident activity, together with the EPSPs generated by the conditioned stimulus, leads to calcium ent”
Assembly of a β2‐adrenergic receptor—GluR1 signalling complex for localized cAMP signalling (2010, background): “Injection of the catalytically active BoTox or TeTox light chain does not reduce basal postsynaptic responses, but abrogates LTP (Lledo et al, 1998; Lu et al, 2001).”
Balancing structure and function at hippocampal dendritic spines. (2008, background): “Aakalu et al. 2001; Havik et al. 2003; Kennedy et al. 1983, 1990; Liao et al. 1995; Lledo et al. 1995; Martone et al. 1996; McGlade-McCulloh et al. 1993; Ouyang et al. 1997, 1999; Pettit et al. 1994 Actin Regulates the extension of filopodia and mediates the expansion of spine heads with LTP and…”
Regulatory mechanisms of AMPA receptors in synaptic plasticity (2007, background): “, and the GluR1 subunit seems to be crucially involved in this activity-dependent delivery of AMPARs to synapses in LT”
Soluble Aβ oligomers inhibit long-term potentiation through a mechanism involving excessive activation of extrasynaptic NR2B-containing NMDA receptors (2011, background): “Synaptic NMDARs are important for LTP, whereas extrasynaptic NMDARs can trigger de novo long-term depression (LTD) under certain conditions (Lu et al., 2001; Massey et al., 2004).”
NMDA Receptor Subunits Have Differential Roles in Mediating Excitotoxic Neuronal Death Both In Vitro and In Vivo (2007, background): “…activated by glutamate spontaneously released from presynaptic terminals under nonstimulated conditions but not extrasynaptic NMDA receptors, which are not activated under the nonstimu- lated condition because of the low ambient level of extracellular glutamate (Lu et al., 2001; Man et al., 2003).”
MAPK cascade signalling and synaptic plasticity (2004, background): “Several recent publications indicate that an increase in the number and/or activity of postsynaptic AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid)-type glutamate receptors (AMPARs) is a key step in LT”
Differential Regulation of AMPA Receptor and GABA Receptor Trafficking by Tumor Necrosis Factor-α (2005, background): “However, glycine treatment caused an increase in surface expression of both GluR1 and GluR2 (Lu et al., 2001; Man et al., 2003), although we observed a large increase in surface GluR1 with TNF but no significant change in surface GluR2.”