Severe sepsis and septic shock
By Christa A. Schorr, S. Zanotti, R. Dellinger. Virulence, 2013
2,109 citations recorded by the source corpus.
Morbidity and mortality from sepsis remains unacceptably high. Large variability in clinical practice, plus the increasing awareness that certain processes of care associated with improved critical care outcomes, has led to the development of clinical practice guidelines in a variety of areas related to infection and sepsis. The Surviving Sepsis Guidelines for Management of Severe Sepsis and Septic Shock were first published in 2004, revised in 2008, and recently revised again and published in 2013. The first part of this manuscript is a summary of the 2013 guidelines with some editorial comment. The second part of the manuscript characterizes hospital based sepsis performance improvement programs and highlights the sepsis bundles from the Surviving Sepsis Campaign as a key component of such a program.
Subfields: Critical Care and Intensive Care Medicine, Epidemiology
View Paper: https://www.semanticscholar.org/paper/8d2e31e678baea4836db54d285eb6568ec404b87
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In Critical Care and Intensive Care Medicine
In Epidemiology
Citations in the corpus
- The Timing of Early Antibiotics and Hospital Mortality in Sepsis (2017, background): “This has motivated international guidelines and quality benchmarks in sepsis care (1, 3, 4).”
- Non-canonical proteolytic activation of human prothrombin by subtilisin from Bacillus subtilis may shift the procoagulant–anticoagulant equilibrium toward thrombosis (2017, background): “strategies, the pathological activation of coagulation in infectious diseases is associated with high morbidity and mortality (22, 68).”
- Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis. (2019, neutral): “4-6) 5 (2-12) 16 (9-32) 13 (4-30) Erythrocyte sedimentation rate, median (IQR), mm/h 48 (25-88) 28 (15-45) 61 (38-99) 92 (59-116) 31 (14-55)”
- Enhancing Recovery From Sepsis (2018, positive): “Second, the characteristics of immune system changes vary and depend on both host and pathogen characteristics, as well as recent medical events (eg, surgery, other infection) and treatment (eg, timing of antibiotics).(17) Third, the resolution of immune system changes in response to sepsis is compl”