Antibiotics versus biofilm: an emerging battleground in microbial communities
By D. Sharma, Lama Misba, Asad U. Khan. Antimicrobial Resistance and Infection Control, 2019
1,317 citations recorded by the source corpus.
Biofilm is a complex structure of microbiome having different bacterial colonies or single type of cells in a group; adhere to the surface. These cells are embedded in extracellular polymeric substances, a matrix which is generally composed of eDNA, proteins and polysaccharides, showed high resistance to antibiotics. It is one of the major causes of infection persistence especially in nosocomial settings through indwelling devices. Quorum sensing plays an important role in regulating the biofilm formation. There are many approaches being used to control infections by suppressing its formation but CRISPR-CAS (gene editing technique) and photo dynamic therapy (PDT) are proposed to be used as therapeutic approaches to subside bacterial biofim infections, especially caused by deadly drug resistant bad bugs.
Subfields: Biomedical Engineering, Endocrinology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/8cf2462d3d8dbab72f2b190b19d9251da89b9d3c
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Citations in the corpus
- Understanding bacterial biofilms: From definition to treatment strategies (2023, background): “Due to the phenotypic diversity of bacterial biofilms, the content of antimicrobials entering the biofilms will be reduced, and the microenvironment within the biofilms will be changed, causing the biofilms’ resistance mechanism to antibiotics (Sharma et al., 2019), making it difficult to eradicate.”
- Microbial Biofilm: A Review on Formation, Infection, Antibiotic Resistance, Control Measures, and Innovative Treatment (2023, neutral): “Bacteria in the planktonic state are known to use either enzymes, efflux pumps, or mutations as a means to evade drugs and develop resistance [131–139].”