Nanomaterial-based therapeutics for antibiotic-resistant bacterial infections
By J. M. Makabenta, Ahmed Nabawy, Cheng-Hsuan Li, Suzannah M. Schmidt-Malan, Robin Patel, Vincent Rotello. Nature Reviews Microbiology, 2020
1,143 citations recorded by the source corpus.
Antibiotic-resistant bacterial infections arising from acquired resistance and/or through biofilm formation necessitate the development of innovative ‘outside of the box’ therapeutics. Nanomaterial-based therapies are promising tools to combat bacterial infections that are difficult to treat, featuring the capacity to evade existing mechanisms associated with acquired drug resistance. In addition, the unique size and physical properties of nanomaterials give them the capability to target biofilms, overcoming recalcitrant infections. In this Review, we highlight the general mechanisms by which nanomaterials can be used to target bacterial infections associated with acquired antibiotic resistance and biofilms. We emphasize design elements and properties of nanomaterials that can be engineered to enhance potency. Lastly, we present recent progress and remaining challenges for widespread clinical implementation of nanomaterials as antimicrobial therapeutics. In this Review, Rotello and colleagues discuss the mechanisms by which nanomaterials can be used to target antibiotic-resistant bacterial infections, highlight design elements and properties of nanomaterials that can be engineered to enhance potency, and explore recent progress and remaining challenges for clinical implementation of nanomaterials as antimicrobial therapeutics.
Subfields: Biomedical Engineering, Molecular Biology, Organic Chemistry
View Paper: https://www.semanticscholar.org/paper/8ce46e8d5bfe5373f1322846f0276f74d74e0961
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Citations in the corpus
- Understanding bacterial biofilms: From definition to treatment strategies (2023, background): “Nanomaterials are effective carriers of antibacterial agents and inhibit the growth of biofilms through thermal damage, oxidative stress, and physical damage, which is conducive to the treatment of bacterial biofilm infection (Makabenta et al., 2021), and are not prone to drug resistance (Pelgrift a”