The Third Generation Cohort of the National Heart, Lung, and Blood Institute's Framingham Heart Study: design, recruitment, and initial examination.

By G. L. Splansky, D. Corey, Qiong Yang, L. Atwood, L. Cupples, Emelia J. Benjamin, Ralph B. D’Agostino, Caroline S. Fox, Martin G. Larson, Joanne M. Murabito and 4 more. American Journal of Epidemiology, 2007

876 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Genetics, Health, Toxicology and Mutagenesis

View Paper: https://www.semanticscholar.org/paper/8c9c2509d53ba1c02d3b0c2fc48be3810d0a7cf7

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In Cardiology and Cardiovascular Medicine

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Citations in the corpus

Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study (2008, background): “In 2002, the Third Generation, representing the children of the Offspring cohort, was recruited (n=4095) (21).”
Adiposity, Cardiometabolic Risk, and Vitamin D Status: The Framingham Heart Study (2009, positive): “Beginning in 2002, 4,095 Third Generation Study participants, who had at least one parent in the Offspring cohort, were also enrolled and underwent standardized clinic examinations at the Heart Study between 2002 and 2005 (21).”
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer’s disease (2013, background): “It now comprises three generations of participants including the Original cohort followed since 1948 (n=5,209) [37], their Offspring and spouses of the offspring (n=5,216) followed since 1971 [38]; and children from the largest Offspring families enrolled in 2000 (Gen 3) [39].”
Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits (2011, background): “In 2002, 4,095 third generation members and their spouses were enrolled [43].”
Reduced signal for polygenic adaptation of height in UK Biobank (2018, methodology): “…an earlier version of GIANT, published by ( Lango Allen et al., 2010 ) were statistically consistent with effect sizes re-estimated in a smaller sibling-based regression approach using data from the Framingham Heart Study (4819 individuals across 1761 nuclear sibships from Splansky et al., 2007 ).”
A computational solution for bolstering reliability of epigenetic clocks: Implications for clinical trials and longitudinal tracking (2021, background): “The FHS Offspring and Third Generation cohorts have previously been described 57,58 .”
Spinal stenosis prevalence and association with symptoms: The Framingham Study (2009, methodology): “A description of the Offspring and Third Generation cohorts has been previously reported [6].”
Avoiding the high Bonferroni penalty in genome-wide association studies (2009, methodology): “For the second data set, we used the Affymetrix GeneChip® Human Mapping 500K Array Set, from the Framingham Heart Study [Splansky, et al. 2007] (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gap).”