Thyroid imaging reporting and data system for US features of nodules: a step in establishing better stratification of cancer risk.

By J. Kwak, Kyunghwa Han, Jung Hyun Yoon, H. Moon, E. Son, So Hee Park, H. K. Jung, J. Choi, Bo Mi Kim, Eun-Kyung Kim. Radiology, 2011

1,077 citations recorded by the source corpus.

PURPOSE To develop a practical thyroid imaging reporting and data system (TIRADS) with which to categorize thyroid nodules and stratify their malignant risk. MATERIALS AND METHODS The institutional review board approved this retrospective study, and the requirement to obtain informed consent for the review of images and records was waived. From May to December 2008, ultrasonographically (US)-guided fine-needle aspiration biopsy (FNAB) was performed in 3674 focal thyroid nodules in 3414 consecutive patients. The study included the 1658 thyroid nodules (≥1 cm in maximum diameter at US) in 1638 patients (1373 women, 265 men) for which pathologic diagnosis or follow-up findings were available. Univariate and multivariate analyses with generalized estimating equations were performed to investigate the relationship between suspicious US features and thyroid cancer. A score for each significant factor was assigned and multiplied by the β coefficient obtained for each significant factor from multivariate logistic regression analysis. Scores for each significant factor were then added, resulting in an equation that fitted the probability of malignancy in thyroid nodules. The authors evaluated the fitted probability by using a regression equation; the risk of malignancy was determined according to the number of suspicious US features. RESULTS The following US features showed a significant association with malignancy: solid component, hypoechogenicity, marked hypoechogenicity, microlobulated or irregular margins, microcalcifications, and taller-than-wide shape. As the number of suspicious US features increased, the fitted probability and risk of malignancy also increased. Positive predictive values according to the number of suspicious US features were significantly different (P < .001). CONCLUSION Risk stratification of thyroid malignancy by using the number of suspicious US features allows for a practical and convenient TIRADS.

Subfields: Endocrinology, Diabetes and Metabolism, Surgery

View Paper: https://www.semanticscholar.org/paper/8c8f529b68322c51ebc88219f79d97e093f6c473

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

E. J. Ha
J. Baek
J. Shin
J. Kwak
Jin Chung
W. Moon
Ji-hoon Kim
Young Hen Lee

Citations in the corpus

Ultrasonography Diagnosis and Imaging-Based Management of Thyroid Nodules: Revised Korean Society of Thyroid Radiology Consensus Statement and Recommendations (2016, methodology): “It has been investigated for its ability for the quantitative estimation of the malignancy risk using scoring systems based on the categorization of the US patterns (25, 86, 87) or based on the calculation of the number of suspicious US features and US risk scores (24, 39, 88).”
2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer (2009, neutral): “The vast majority (82%–91%) of thyroid cancers are solid (70,73,75,77,84).”