Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets.

By J. Pelletier, J. Martel-Pelletier, S. Abramson. Arthritis & Rheumatism, 2001

1,096 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Matrix metalloproteinases: role in arthritis. (2006, background): “This pathway develops as cartilage breakdown products are released into the joint fluid and irritate the synovial membranes lining the joint space (18).”
Significant association of interleukin-4 gene intron 3 VNTR polymorphism with susceptibility to knee osteoarthritis. (2014, background): “Ultimately, chondrocyte malfunction and apoptosis limit the response potential and hasten the progression of OA (Pelletier et al., 2001; Sandell and Aigner, 2001).”
The role of cytokines in cartilage matrix degeneration in osteoarthritis. (2004, background): “growth and differentiation factors on chondrocytes to increase synthetic activity.(47,75,81,108,143) In addition, several cytokines can be classified as modulatory based on their capacity to modulate the activities of the other cytokines (Table 1).”
The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis (2010, background): “They decrease the release of PGE 2 , IL-1β, TNF and MMPs, and stimulate the production of IL-1Ra and TIMP”