Mitochondrial TCA cycle metabolites control physiology and disease

By I. Martínez-Reyes, Navdeep S. Chandel. Nature Communications, 2020

2,297 citations recorded by the source corpus.

Mitochondria are signaling organelles that regulate a wide variety of cellular functions and can dictate cell fate. Multiple mechanisms contribute to communicate mitochondrial fitness to the rest of the cell. Recent evidence confers a new role for TCA cycle intermediates, generally thought to be important for biosynthetic purposes, as signaling molecules with functions controlling chromatin modifications, DNA methylation, the hypoxic response, and immunity. This review summarizes the mechanisms by which the abundance of different TCA cycle metabolites controls cellular function and fate in different contexts. We will focus on how these metabolites mediated signaling can affect physiology and disease. Mitochondrial metabolites contribute to more than biosynthesis, and it is clear that they influence multiple cellular functions in a variety of ways. Here, Martínez-Reyes and Chandel review key metabolites and describe their effects on processes involved in physiology and disease including chromatin dynamics, immunity, and hypoxia.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8c3b7c2ed33880607083f58b0582ef7a49588008

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Citations in the corpus

Mitochondrial dysfunction: mechanisms and advances in therapy (2024, background): “75 These feed into the tricarboxylic acid (TCA) cycle, further fueling electron transport and ATP production.”
Macrophages in immunoregulation and therapeutics (2023, background): “IRF3 tracks the secretion of IFNs, including IFN-α and IFN-β.”