Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ.

By D. Doyle, Alice Lee, John H. Lewis, Eunjoon Kim, M. Sheng, R. MacKinnon. 1996

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Citations in the corpus

Revealing evolutionary constraints on proteins through sequence analysis (2018, background): “ protein properties [11,20{22], including the emergence of allostery [23{29]. Thus motivated, we begin by building an elastic-network model [11,20] for a well-studied PDZ protein domain (Fig. 1(a,b)) [30,31] and computing the relationship between its \sequence" and the energetic cost of a funct”
Protein sectors: evolutionary units of three-dimensional structure (2009, background): “(A) The blue and red sectors of the PDZ family, respectively, shown as spheres within a molecular surface on a member of the protein family (PDB 1BE9 [Doyle et al., 1996]; substrate peptide in green stick bonds).”
The Human Papillomavirus E6 protein and its contribution to malignant progression (2001, unknown): “Moreover, the binding motif on E6 is small and exposed, and the structures of a number of PDZ domains have been solved (Doyle et al., 1996; Tochio et al., 2000).”
Structure of TPR domain-peptide complexes: critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine. (2000, background): “…domain bound with a significantly A Comparison with Other Peptide Binding Domains Another class of protein domain that binds to C-terminalreduced affinity (250 mM), suggesting steric incompatibility of the C70 domain with TPR2A. sequences of target proteins is the PDZ domain (Doyle et al., 1996).”
PDZ Domain Proteins: Plug and Play! (2003, background): “The solved three-dimensional structures of several PDZ domains, complexed with their respective ligands or ligand-free, have elucidated the mechanism of PDZ domain interactions ( 17 - 19 ).”
Functional dynamics of PDZ binding domains: a normal-mode analysis. (2005, background): “To explore the different role of the PDZ topology with respect to its chemistry in determining the binding movements, we have shifted from the CHARMM force-field, where both topology and full chemical details are taken into account, to the ANM description in its Cβ version, which deals only with the”