Hyaluronic Acid Hydrogels for Biomedical Applications

By Jason A. Burdick, Glenn D. Prestwich. Advances in Materials, 2011

1,934 citations recorded by the source corpus.

Hyaluronic acid (HA), an immunoneutral polysaccharide that is ubiquitous in the human body, is crucial for many cellular and tissue functions and has been in clinical use for over thirty years. When chemically modified, HA can be transformed into many physical forms—viscoelastic solutions, soft or stiff hydrogels, electrospun fibers, non‐woven meshes, macroporous and fibrillar sponges, flexible sheets, and nanoparticulate fluids—for use in a range of preclinical and clinical settings. Many of these forms are derived from the chemical crosslinking of pendant reactive groups by addition/condensation chemistry or by radical polymerization. Clinical products for cell therapy and regenerative medicine require crosslinking chemistry that is compatible with the encapsulation of cells and injection into tissues. Moreover, an injectable clinical biomaterial must meet marketing, regulatory, and financial constraints to provide affordable products that can be approved, deployed to the clinic, and used by physicians. Many HA‐derived hydrogels meet these criteria, and can deliver cells and therapeutic agents for tissue repair and regeneration. This progress report covers both basic concepts and recent advances in the development of HA‐based hydrogels for biomedical applications.

Subfields: Biomedical Engineering, Cell Biology, Molecular Medicine

View Paper: https://www.semanticscholar.org/paper/8bd240e8e4f01fe62bd6e174bbb6e7070fd4d7c1

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Citations in the corpus

A practical guide to hydrogels for cell culture (2016, background): “…dialog between cell biologists and materials scientists and engineers so that the next generation of hydrogel systems will be equipped to tackle important challenges of increasing biological complexity. crosslinking chemistries is perhaps its biggest advantage and has been reviewed elsewhere 74 .”
Recent Advances in Bioink Design for 3D Bioprinting of Tissues and Organs (2017, background): “Many natural polymers (such as gelatin and HA) have functionalizable backbone side chains enabling them to be functionalized with chemical moieties to induce cross-linking (chemical- and/ or photo-cross-linking) or additional bioactivity (Burdick and Prestwich, 2011).”
Overview of natural hydrogels for regenerative medicine applications (2019, background): “diseases due to their properties of anti-inflammation and biocompatibility [61].”
Three-Dimensional in Vitro Cell Culture Models in Drug Discovery and Drug Repositioning (2018, background): “…the best characterized natural hydrogels is hyaluronic acid (HA)—a glycosaminoglycan that can be modified with functional groups, allowing for the formation of hydrogels with diverse properties for a wide range of applications (Burdick and Prestwich, 2011; Baeva et al., 2014; Goubko et al., 2014).”
Hyaluronan: A Simple Polysaccharide with Diverse Biological Functions (2013, background): “Many HA-derived medical products have been developed and tested, and readers are referred to recent reviews [17,175] for in-depth analyses.”
Emerging trends and new developments in regenerative medicine: a scientometric update (2000 – 2014) (2014, background): “1 Warren et al. (2010) CELL STEM CELL, V7, P618 [45] 113.0 2011 2014 2 Kim et al. (2010) NATURE, V467, P285 [32] 102.8 2011 2014 3 Vierbuchen et al. (2010) NATURE, V463, P1035 [23] 93.7 2011 2014 4 Ieda et al. (2010) CELL, V142, P375 [22] 90.7 2011 2014 5 Lister et al. (2011) NATURE, V471, P68 [46] ”
Current development of biodegradable polymeric materials for biomedical applications (2018, background): “69 72 As HA is secreted at the early stage of wound healing, it has been extensively researched for wound-dressing applications.”