Reinsertion or degradation of AMPA receptors determined by activity-dependent endocytic sorting.

By Michael D. Ehlers. Neuron, 2000

1,149 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8ba3fff2c81aa2a1e28b895f54dc7938b0931f9d

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In Cellular and Molecular Neuroscience

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Citations in the corpus

PKA phosphorylation of AMPA receptor subunits controls synaptic trafficking underlying plasticity (2003, background): “In addition, GluR1 recycling between the plasma membrane and endosomal compartments is controlled by PKA phosphorylation in dissociated hippocampal neuron”
AMPA Receptor Trafficking and the Control of Synaptic Transmission (2001, background): “…Model of AMPA Receptor Trafficking The subunit-specific regulation of AMPA receptor deliv-are relatively stable on the cell surface (Lin et al., 2000; Ehlers, 2000). ery to synapses inspires the following model of AMPA receptor trafficking at a hippocampal synapse (FigureAfter endocytosis, most of…”
Regulation of AMPA Receptor Trafficking and Synaptic Plasticity (2012, background): “Current Opinion in Neurobiology 2012, 22:461–469 type of stimulation, internalized AMPARs undergo complex endosomal sorting processes that direct receptors either to recycle back to the plasma membrane or to be degraded by the lysosomal pathway [17,18].”
Compartmentalizing the neuronal plasma membrane from axon initial segments to synapses. (2009, background): “Because NMDA receptor-stimulated AMPA receptor endocytosis requires Ca2þ influx, Ca2þ sensing molecules, such as calcineurin (PP2B), hippocalcin, and PICK, are involved in regulating AMPAR endocytosis probably through facilitating the interaction between AMPAR and endocytic machinery (Beattie et al.”
Assembly of a β2‐adrenergic receptor—GluR1 signalling complex for localized cAMP signalling (2010, background): “Phosphorylation of S845 by PKA promotes GluR1 surface expression because of a combination of reduced internaliza- tion rate and increased re-insertion rate (Ehlers, 2000; Man et al, 2007).”
NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD). (2012, background): “In addition, in ways that remain to be determined, the increase in CaMKII activity contributes to the insertion of AMPARs (Ehlers 2000).”
Homeostatic plasticity in the developing nervous system (2004, background): “On the other hand, a process that speeds up (or slows down) the constitutive rate of receptor insertion will scale up (or down) the steady-state number of receptors across all synapses proportionally, as is observed after prolonged inactivit”
Differential Regulation of AMPA Receptor and GABA Receptor Trafficking by Tumor Necrosis Factor-α (2005, methodology): “It is possible that the antibodies to GluR1 might somehow sterically inhibit antibody staining of surface GluR2, and, therefore, we used an alternative technique, biotinylation of surface AMPARs (Ehlers, 2000; Kim and von Zastrow, 2003), to reexamine whether GluR2 surface expression was increased by”
Synaptic Plasticity: Multiple Forms, Functions, and Mechanisms (2008, background): “Key substrates for facilitating endocytosis may include components of the endocytic machinery (Carroll et al, 2001; Lai et al, 1999; Slepnev et al, 1998) as well as AMPAR subunits themselves (Ehlers, 2000).”
Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memory. (2003, methodology): “Moreover, the internalization and recycling of AMPA receptors has been correlated with changes in S845 phosphorylation (Ehlers, 2000).”