Novel application of HKUST-1 metal–organic framework as antifungal: Biological tests and physicochemical characterizations

By C. Chiericatti, J. Basílico, M. Basilico, J. M. Zamaro. 2012

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Abstract The HKUST-1 metal–organic framework (MOF) was successfully applied as a biocidal material against representative yeast and mold. The synthesized MOF showed a strong antifungal effect against Saccharomyces cerevisiae for which the growth was completely inhibited, whereas the growth of Geotrichum candidum was reduced from 6.16 to 1.29 CFU mL −1 . The antifungal action was related to copper ions released into the culture medium due to a progressive degradation of the crystalline structure of the material that involved the formation of surface extra-framework Cu(I). This study shows the potential of using copper-based metal–organic frameworks for a controlled release of biologically active copper ions.

Subfields: Industrial and Manufacturing Engineering, Inorganic Chemistry, Materials Chemistry

View Paper: https://www.semanticscholar.org/paper/8b10dd12da47e45314320d10813d9d0e2123ba20