Prediabetes: A high-risk state for developing diabetes
By Á. Tabák, C. Herder, W. Rathmann, E. Brunner, M. Kivimaki. The Lancet, 2012
2,606 citations recorded by the source corpus.
Summary Prediabetes (or “intermediate hyperglycaemia”), based on glycaemic parameters above normal but below diabetes thresholds is a high risk state for diabetes with an annualized conversion rate of 5%–10%; with similar proportion converting back to normoglycaemia. The prevalence of prediabetes is increasing worldwide and it is projected that >470 million people will have prediabetes in 2030. Prediabetes is associated with the simultaneous presence of insulin resistance and β-cell dysfunction, abnormalities that start before glucose changes are detectable. Observational evidence shows associations of prediabetes with early forms of nephropathy, chronic kidney disease, small fibre neuropathy, diabetic retinopathy, and increased risk of macrovascular disease. Multifactorial risk scores could optimize the estimation of diabetes risk using non-invasive parameters and blood-based metabolic traits in addition to glycaemic values. For prediabetic individuals, lifestyle modification is the cornerstone of diabetes prevention with evidence of a 40%–70% relative risk reduction. Accumulating data also suggests potential benefits from pharmacotherapy.
Subfields: Endocrinology, Diabetes and Metabolism, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/8af1cd7ee33272c0efbee0d0e6e9ff096de57d03
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Citations in the corpus
- Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. (2014, background): “Epidemiology The burden of DM is rising in both developed and developing countries.89–91 In the United States, 11.3% of adults have diagnosed or occult DM.90,92 The actual prevalence increases significantly with age so that prevalence rises from 3.7% among US adults aged 20 to 44 years to 26.9% amon”
- Sex and Gender Differences in Risk, Pathophysiology and Complications of Type 2 Diabetes Mellitus (2016, background): “There are several diabetes risk scores, including sex in risk calculations together with various other risk parameters, but only a few include WCR or social factors like social deprivation (37, 38).”