Dysregulation of TGF-β activation contributes to pathogenesis in Marfan syndrome

By E. Neptune, P. Frischmeyer, Dan E. Arking, Loretha A Myers, T. Bunton, B. Gayraud, F. Ramirez, L. Sakai, H. Dietz. Nature Genetics, 2003

1,286 citations recorded by the source corpus.

Subfields: Genetics, Pulmonary and Respiratory Medicine, Surgery

View Paper: https://www.semanticscholar.org/paper/8ada6eef133e10660f81dc3bbc1032b9211c57c5

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. P. ten Dijke

In Pulmonary and Respiratory Medicine

1. E. Morrisey
2. D. Sheppard
3. B. Hogan

In Surgery

1. B. Hogan

Citations in the corpus

• Extracellular control of TGFβ signalling in vascular development and disease (2007, background): “Reduced fibrillin-1 may result in incorrect LLC sequestration and excessive activation of TGFβ signalling, a major contributory factor in the vascular pathology of MF”
• Preparing for the First Breath: Genetic and Cellular Mechanisms in Lung Development (2010, background): “These may function in part by specifically binding and acting as a “sink” for growth factors (such as Tgfβ) required for coordinating development (Neptune et al., 2003).”
• TGF-β Activation and Function in Immunity (2013, background): “fibrillin 1 develop pulmonary emphysema and aortic aneurysms (148).”